Microdosing 101: A Complete Guide to Deadhead Chemist 1P-LSD

Disclaimer: This guide is intended to support the safe and informed use of 1P-LSD where legal. LSD and its analogues are controlled substances in many jurisdictions. We do not encourage or condone illegal activity. Always consult your local laws before acquiring or using any psychedelic substances.

What is 1P-LSD?

1P-LSD, or 1-Propionyl-lysergic acid diethylamide, is a synthetic psychedelic compound closely related to LSD. It’s considered a prodrug, meaning it metabolizes into LSD after ingestion. While its effects are often described as similar to LSD, some users report slight differences in onset and duration.

In the context of microdosing, the goal is not to “trip,” but to experience subtle cognitive or emotional enhancements. A typical microdose of 1P-LSD ranges between 5 to 15 micrograms (µg)—far below the threshold for full-blown psychedelic effects.

How to Prepare and Use 1P-LSD

If using 1P-LSD in liquid form:

Dilute 100 µg of 1P-LSD in 10 mL of distilled water or ethanol for accurate dosing (10 µg per mL).
Store in a sealed container in the refrigerator (not freezer).
Shake gently before each use to ensure even distribution.

Use a micro-pipette or syringe for accurate dosing. Always measure doses carefully to avoid accidental overconsumption.

Benefits of Microdosing 1P-LSD (Anecdotal Reports)

Enhanced mood and reduced symptoms of depression and anxiety
Increased creativity and problem-solving ability
Improved focus and mental clarity
Heightened empathy and social connection
Increased motivation and energy levels
Boosted self-esteem and confidence

Scientific research on microdosing is ongoing. Most benefits reported so far are based on anecdotal evidence.

How to Microdose

Microdosing involves taking a sub-perceptual dose of a psychedelic, usually every few days, to avoid building tolerance and maintain efficacy.

Suggested protocol (James Fadiman’s Schedule):

Day 1: Microdose
Day 2: No dose (observe effects)
Day 3: No dose (observe residual effects)
Day 4: Microdose again

Start with 10-15 µg of 1P-LSD. Track your mood, energy, focus, and any side effects in a journal. Adjust dosage as needed to find your “sweet spot.”

Flow States and Brain Function

Microdosing may promote a “flow state”—a state of deep focus and immersion in tasks. This is believed to occur because psychedelics:

Shift brainwave activity toward alpha oscillations
Increase levels of serotonin and dopamine
Temporarily suppress the Default Mode Network (DMN), enhancing cross-talk between brain regions

These effects are speculative and require more scientific investigation, but they align with the experiences reported by many microdosers.

Important Precautions

Do not microdose daily: Frequent use can lead to tolerance and diminished effects.
Avoid use if you have a history of heart issues or psychiatric disorders.
Take your first microdose on a day off to assess your body’s response.
Keep records of your experiences to better understand the effects over time.

Legal Considerations

1P-LSD is a grey-area substance legally.

United States: Not federally scheduled, but may be restricted under analog laws.
United Kingdom: Controlled under the Psychoactive Substances Act.
Germany & Netherlands: Sold online; legality varies by local jurisdiction.
Canada & Finland: Not scheduled, but laws may still prohibit human consumption.

Always research local regulations before purchase or use.

Reported Side Effects (20–100 µg range)

Increased anxiety or emotional sensitivity
Mild headaches
Restlessness
Temporary insomnia
Enhanced visual perception (at higher doses)
Impaired judgment (if not microdosed properly)

Final Thoughts

Microdosing 1P-LSD offers potential cognitive and emotional benefits when approached mindfully and responsibly. It’s essential to respect the compound, dose carefully, monitor effects, and stay within the bounds of the law. As research continues to evolve, users and scientists alike are learning more about the profound potential of microdosing psychedelics.