4-AcO-DMT Deadhead Chemist

4-AcO-DMT O-Acetylpsilocin

4-Acetoxy-N,N-dimethyltryptamine (also known as 4-AcO-DMT, 4-Acetoxy-DMT, O-Acetylpsilocin, psilacetin, and “synthetic mushrooms”) is a novel, lesser-known psychedelic substance of the tryptamine class. It is structurally related to psilocybin and psilocin, the active ingredients in psilocybin mushrooms (“magic mushrooms”). 4-AcO-DMT produces its effects by binding to serotonin receptors in the brain.

However, the precise mechanism is not known.

4-AcO-DMT was first synthesized in 1963 by Albert Hofmann and Franz Troxler.

as part of a chemical investigation into psilocin analogs. ^[1]However, it was not tested for psychoactivity during this time. It is unknown when it was first explored in humans. A paper authored by David E. Nichols in 1999 proposed its potential use as an alternative to psilocybin for pharmacological research due to the lower cost of synthesis. ^[2]Reports of recreational use began to surface shortly after its appearance on the online research chemical market in the 2010s. ^{[citation needed]}

Subjective effects include geometric visual effects, time distortion, enhanced introspection, euphoria, and ego loss. 4-AcO-DMT’s effects are considered to be nearly identical to psilocybin, with some subtle differences. It has been theorized to act as a prodrug to psilocin, like psilocybin, which may account for this similarity. 4-AcO-DMT’s classical psychedelic effects and favorable tolerability profile have led it to become popular among novel psychoactive substance users who seek mystical or entheogenic experiences. It is occasionally sold in capsules or pressed pills and marketed as “synthetic shrooms.”

Very little data exists on the pharmacology, metabolism, and toxicity of 4-AcO-DMT. Although its toxicity profile is believed to be nearly identical to psilocybin mushrooms (see this section), which are known to be physiologically non-toxic, there is no hard data to support this claim. It is highly advised to use harm reduction practices if using this substance.